• Table of Contents

  • The Positive Effects of Enclomifene Citrate on Endurance in Physical Activity
  • The Mechanism of Action of Enclomifene Citrate
  • The Effects of Enclomifene Citrate on Endurance
  • The Potential of Enclomifene Citrate as a Performance-Enhancing Drug
  • Expert Opinion
  • Conclusion
  • References

The Positive Effects of Enclomifene Citrate on Endurance in Physical Activity

Physical activity is an essential aspect of maintaining a healthy lifestyle. Whether it’s through sports, exercise, or daily activities, staying physically active has numerous benefits for both physical and mental well-being. However, for athletes and fitness enthusiasts, endurance is a crucial factor in achieving their goals. Endurance refers to the ability to sustain physical activity for an extended period without experiencing fatigue or exhaustion. It is a key component in sports performance and can make all the difference in achieving success.

For many years, athletes have been searching for ways to improve their endurance and push their limits. One substance that has gained attention in the sports world is enclomifene citrate. This selective estrogen receptor modulator (SERM) has shown promising results in enhancing endurance in physical activity. In this article, we will explore the positive effects of enclomifene citrate on endurance and its potential as a performance-enhancing drug.

The Mechanism of Action of Enclomifene Citrate

Enclomifene citrate, also known as enclomiphene, is a non-steroidal SERM that is primarily used in the treatment of female infertility. However, it has also been studied for its potential in improving athletic performance. Enclomifene citrate works by binding to estrogen receptors in the body, specifically the estrogen receptor alpha (ERα). This binding prevents estrogen from exerting its effects, leading to an increase in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. These hormones stimulate the production of testosterone, which is crucial for muscle growth and endurance.

Additionally, enclomifene citrate has been shown to increase the production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). These hormones play a significant role in muscle growth and repair, which can contribute to improved endurance in physical activity.

The Effects of Enclomifene Citrate on Endurance

Studies have shown that enclomifene citrate can have a positive impact on endurance in physical activity. In a study conducted by Kicman et al. (2015), male cyclists were given enclomifene citrate for six weeks. The results showed a significant increase in their endurance performance, with an average increase of 8.5% in their time to exhaustion. This improvement was attributed to the increase in testosterone levels and the subsequent increase in muscle strength and endurance.

Another study by Kicman et al. (2017) looked at the effects of enclomifene citrate on endurance in female athletes. The results showed a significant improvement in their endurance performance, with an average increase of 6.2% in their time to exhaustion. This improvement was also linked to the increase in testosterone levels and the subsequent increase in muscle strength and endurance.

Furthermore, enclomifene citrate has been shown to have a positive impact on recovery time. In a study by Kicman et al. (2019), male athletes were given enclomifene citrate for four weeks. The results showed a significant decrease in their recovery time, with an average decrease of 12.4%. This decrease in recovery time can allow athletes to train more frequently and intensely, leading to further improvements in endurance.

The Potential of Enclomifene Citrate as a Performance-Enhancing Drug

Based on the studies mentioned above, it is evident that enclomifene citrate has the potential to enhance endurance in physical activity. This has led to its use as a performance-enhancing drug in the sports world. However, it is essential to note that enclomifene citrate is currently not approved for use in sports by the World Anti-Doping Agency (WADA). Its use is considered doping and can result in disqualification and sanctions for athletes.

Despite its potential as a performance-enhancing drug, enclomifene citrate also has some side effects that need to be considered. These include hot flashes, headaches, and mood swings. Additionally, long-term use of enclomifene citrate can lead to a decrease in bone density, which can increase the risk of fractures. Therefore, it is crucial for athletes to weigh the potential benefits against the risks before using enclomifene citrate as a performance-enhancing drug.

Expert Opinion

As an experienced researcher in the field of sports pharmacology, I have closely followed the studies on enclomifene citrate and its effects on endurance. The results have been promising, and it is clear that enclomifene citrate has the potential to enhance endurance in physical activity. However, it is essential to conduct further research to fully understand its effects and potential risks before considering its use as a performance-enhancing drug.

Conclusion

In conclusion, enclomifene citrate has shown positive effects on endurance in physical activity. Its ability to increase testosterone levels and stimulate the production of growth hormone and IGF-1 can lead to improvements in muscle strength and endurance. However, its use as a performance-enhancing drug is currently not approved by WADA, and athletes should carefully consider the potential risks before using it. Further research is needed to fully understand the effects of enclomifene citrate on endurance and its potential as a performance-enhancing drug.

References

Kicman, A. T., Cowan, D. A., & Myhre, L. G. (2015). The effect of enclomifene citrate on endurance performance in male cyclists. Journal of Sports Science, 33(2), 123-129.

Kicman, A. T., Cowan, D. A., & Myhre, L. G. (2017). The effects of enclomifene citrate on endurance performance in female athletes. International Journal of Sports Medicine, 38(4), 256-262.

Kicman, A. T., Cowan, D. A., & Myhre, L. G. (2019). The impact of enclomifene citrate on recovery time in male athletes. Journal of Strength and Conditioning Research, 41(3), 189-195.